Coupling Constants in NMR

Source: http://sopnmr.ucsd.edu/coupling.htm

¹H-¹H coupling

Environment	Coupling	Value (Hz)
Aliphatic, H-C-H, geminal	2JHH	-15 ~ -10
Aliphatic, H-C-C-H	3JHH	6 ~ 8
Aldehyde, H-C-CO-H	3JHH	2 ~ 3
Alkene, H-C-H, geminal	2JHH	0 ~ 3
Alkene, H-C=C-H, trans	3JHH	12 ~ 18
Alkene, H-C=C-H, cis	3JHH	6 ~ 12
Aromatic, H-C=C-H	3JHH	6 ~ 10
Aromatic, H-C-C=C-H	4JHH	1 ~ 3

¹³C-¹H coupling

Environment	Coupling	Value (Hz)
Aliphatic, C-H	1JCH	125 ~ 135
Aliphatic, CX-H (X = N, O, S)	1JCH	135 ~ 155
Alkene, =C-H	1JCH	155 ~ 170
Alkyne, ≡C-H, geminal	1JCH	240 ~ 250
Aromatic, =C-H, trans	1JCH	155 ~ 165

¹⁹F coupling

Environment	Coupling	Value (Hz)
C-F	1JCF	160
C-C-F	2JCF	20 ~ 50
C-C-C-F	3JCF	5
H-C-F	2JHF	40 ~ 60
H-C-C-F	3JHF	2 ~ 15
H-C-C-C-F	4JHF	5

Books for medicinal chemistry

Two books for those organic chemists who want to learn about medicinal chemistry:

Graham Patrick - "An introduction to medicinal chemistry" (6th edition).

Li Di and Edward Kerns - "Drug-like properties: Concept, structure design and methods from ADME to toxicity optimization" (2nd edition).